Italian Sub Grilled Cheese

Featured in: Warm Skillet & Pan Suppers

This Italian-American sandwich brings together classic flavors in a warm, crispy package. Layer provolone, salami, and pepperoni between buttered bread, top with a zesty lettuce mixture dressed in mayo and red wine vinegar, then grill until the cheese melts and the bread turns golden brown. Ready in just 20 minutes, it delivers authentic sub shop satisfaction with every bite.

Updated on Tue, 20 Jan 2026 13:44:00 GMT
Golden-brown Italian Sub Grilled Cheese sandwich stacked with melty provolone, salami, and pepperoni on toasted bread.  Save
Golden-brown Italian Sub Grilled Cheese sandwich stacked with melty provolone, salami, and pepperoni on toasted bread. | dunewhisk.com

The sandwich that started as a desperate pantry cleanout somehow became our Friday night ritual. I had leftover salami from a party, half a head of iceberg lettuce threatening to wilt, and a family staring at me expecting dinner magic. That first bite, the way the crunch of toasted bread met the cool tangy lettuce against salty meat, stopped all conversation at the table.

My brother in law actually requested these for his birthday dinner instead of a restaurant meal. He stood at the stove watching me press them into the pan like he was guarding state secrets. Something about elevating gas station sandwich ingredients into something this ridiculously comforting makes people feel taken care of.

Ingredients

  • Italian bread or sturdy white sandwich bread: The thickness matters here because thin slices will turn to mush under all those toppings and the weight of pressing
  • Unsalted butter softened: Spreads more evenly than cold butter and gives you that even golden crunch without burnt spots
  • Provolone cheese: Its mild creaminess balances the aggressive saltiness of the cured meats without disappearing completely
  • Salami and pepperoni: The fat renders as they grill, infusing the bread with meaty depth that American cheese never achieves
  • Shredded iceberg lettuce: Shredding by hand creates better texture than pre shredded bags which can turn slimy quickly
  • Mayonnaise and red wine vinegar: This combination recreates that sub shop tang that makes your mouth water before you even take a bite
  • Dried oregano: Dried actually works better than fresh here because it distributes evenly through the lettuce mixture

Instructions

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Make the lettuce topping first:
Combine shredded lettuce with mayonnaise, red wine vinegar, oregano, salt, and pepper in a bowl. Mix until every strand of lettuce gets lightly coated, then set aside while you prep everything else. The flavors need these few minutes to meld together.
Prep your bread:
Spread softened butter on one side of each bread slice like you mean it, going all the way to the edges. This butter contact is what creates that golden seal that keeps all the melty goodness inside where it belongs.
Layer like a professional:
Place two slices butter side down and stack provolone first, then salami and pepperoni. The cheese against the bread acts as glue and prevents soggy bottoms from the meat juices.
Add the crunch:
Pile that lettuce mixture right on top of the meats. It might look like too much, but it settles down when you press the sandwich. If you are using pepperoncini or red onion, scatter them now for pockets of bright tang.
Close it up:
Top with remaining bread slices, butter side facing outward. Give each sandwich a gentle press with your palm to help everything settle before they hit the heat.
Grill to perfection:
Cook in a hot skillet over medium heat for 3 to 4 minutes per side. Press down gently with your spatula and listen for that satisfying sizzle. Flip when golden and repeat until the second side matches and cheese is visibly melting.
The crucial resting moment:
Let them sit for just one minute after slicing, otherwise that hot cheese lava will escape everywhere. Then serve immediately while the contrast between hot sandwich and cool lettuce is at its peak.
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Mount paper towels nearby for quick cleanup of spills, grease, and messes while cooking and prepping meals.
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A close-up of a hot Italian Sub Grilled Cheese with crispy crust and melted cheese oozing from the sides.  Save
A close-up of a hot Italian Sub Grilled Cheese with crispy crust and melted cheese oozing from the sides. | dunewhisk.com

My youngest started calling these Friday sandwiches even when I make them on Tuesdays now. There is something about the way the cool lettuce hits the hot meat that makes people slow down and actually sit at the table instead of wandering off with their plates.

Getting That Perfect Golden Crust

The secret is patience with the heat setting. I ruined three sandwiches before learning that medium low gives better results than rushing with high heat. You want the butter to brown slowly while the cheese melts into all the nooks between the meat slices.

Make It Your Own

Sometimes I swap in sharp provolone or add a smear of giardiniera on the bread before layering. The sandwich structure stays the same but small changes keep it from feeling like the same old thing. Last week I tried a drizzle of hot honey and now I cannot decide which version I prefer.

Serving Ideas

Kettle chips on the side feel right because the salt and crunch complement without competing. A simple tomato salad dressed with nothing but salt and olive oil cuts through all the richness. These are substantial enough to stand alone as dinner but light enough that nobody feels comatose afterward.

  • Cut sandwiches on the diagonal, something about the shape makes them taste better
  • Have extra napkins ready because the lettuce mixture can escape a bit on the first bite
  • If serving a crowd, keep finished sandwiches in a 200 degree oven while you grill the rest
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Two halves of an Italian Sub Grilled Cheese served with kettle chips and a side salad on a wooden board. Save
Two halves of an Italian Sub Grilled Cheese served with kettle chips and a side salad on a wooden board. | dunewhisk.com

Hope these bring some crispy melty joy to your kitchen table too.

Your Questions Answered

What type of bread works best for this sandwich?

Italian bread or sturdy white sandwich bread works perfectly. For variations, try whole wheat or sourdough bread for different textures and flavors.

How do I keep the cheese from leaking out while grilling?

Press gently with a spatula while cooking and ensure the bread is well-buttered on the outside. This creates a seal that helps contain the melting cheese inside.

Can I make this sandwich vegetarian?

Yes, omit the salami and pepperoni and add extra provolone, roasted red peppers, sun-dried tomatoes, or caramelized onions for depth and richness.

What's the best way to add heat to this sandwich?

Mix hot giardiniera or extra pepperoncini into the lettuce topping, or add jalapeño slices and a dash of hot sauce for increased spice levels.

How should I serve this sandwich?

Slice in half diagonally and serve immediately while hot. Pair with kettle chips, a simple tomato salad, or pickles for a complete meal.

Can I prepare this sandwich ahead of time?

Assemble the sandwich up to step 5, then cover and refrigerate for up to 2 hours. Grill just before serving for the best texture and melted cheese.

Italian Sub Grilled Cheese

Melty sandwich combining Italian cold cuts, provolone, and tangy lettuce topping grilled to golden perfection.

Time to Prep
10 min
Time to Cook
10 min
Overall Time
20 min
Created by Ella Richardson

Cuisine Category Warm Skillet & Pan Suppers

Skill Level Easy

Cuisine Type Italian-American

Portion Size 2 Number of Portions

Diet Preferences None specified

What You'll Need

Bread & Dairy

01 4 slices Italian bread or sturdy white sandwich bread
02 2 tablespoons unsalted butter, softened
03 4 slices provolone cheese

Meats

01 6 slices salami
02 6 slices pepperoni

Lettuce Topping

01 1 cup shredded iceberg lettuce
02 2 tablespoons mayonnaise
03 1 tablespoon red wine vinegar
04 1 teaspoon dried oregano
05 Salt and freshly ground black pepper to taste

Optional Additions

01 2 tablespoons mild pepperoncini rings, drained
02 2 tablespoons thinly sliced red onion

How To Make It

Step 01

Prepare Lettuce Mixture: In a mixing bowl, combine shredded iceberg lettuce, mayonnaise, red wine vinegar, dried oregano, salt, and freshly ground black pepper. Stir until well blended and set aside.

Step 02

Butter Bread Slices: Lay out all four bread slices on a clean work surface. Spread softened butter evenly on one side of each slice.

Step 03

Layer Base Sandwich: Place two buttered bread slices butter-side down on the work surface. Top each slice with 2 slices of provolone cheese, 3 slices of salami, and 3 slices of pepperoni in that order.

Step 04

Add Optional Toppings: If using pepperoncini rings and red onion, distribute them evenly over the meat and cheese layers on each sandwich base.

Step 05

Spread Lettuce Mixture: Divide the prepared lettuce mixture evenly between the two sandwiches, spreading it in a uniform layer across the meats and cheese.

Step 06

Complete Sandwich Assembly: Top each sandwich with a remaining bread slice, positioning it butter-side up to complete the assembly.

Step 07

Grill Sandwiches: Heat a large skillet or grill pan over medium heat. Place assembled sandwiches in the pan and cook for 3 to 4 minutes per side, applying gentle downward pressure with a spatula until the bread achieves a golden-brown color and the cheese melts completely.

Step 08

Serve: Transfer sandwiches to a cutting board, slice each diagonally in half, and serve immediately while hot.

Tools You Need

  • Large skillet or grill pan
  • Spatula
  • Mixing bowl
  • Knife and cutting board

Allergy Details

Review each item for allergens and speak with a healthcare provider if you're not sure.
  • Contains wheat from bread
  • Contains milk from cheese, butter, and mayonnaise
  • Contains eggs from mayonnaise
  • Contains pork from salami and pepperoni
  • Check all product labels for potential trace allergens

Nutrition Info (per portion)

Nutritional values are for reference and don't substitute for professional guidance.
  • Calorie Count: 540
  • Fats: 34 g
  • Carbohydrates: 35 g
  • Proteins: 24 g